7. Carol Ann Susi: Now
In 2014, at age 62, Carol Ann Susi lost her long-fought battle with lung cancer. She came to The Big Bang Theory with decades of acting experience, including the movie Death Becomes Her, and the cheery movie Cats & Dogs. Her untimely death came as a tough reality for the cast and crew of TBBT. The show’s producers decided to incorporate Susi’s death with the storyline of the show, allowing Howard’s Ma to also die. Her tendency to shout, however, lives on in her daughter-in-law, Bernadette.